Phytochemical composition of BP was determined using the GC-MS. BP significantly reduced macroscopic colonic damage score, weight/length ratio, colonic lipid peroxidation level, leukocytes infiltration, and TNF-α level in comparison to untreated colitic rats (p ≤ 0.008). All articles have to be original articles that have not been published elsewhere or are being considered for publication in other journals. "How to do it" type articles describing new methods or procedures. . for relevant news, product releases and more. Time Spent in the Open Arm was modified by treatment (F=4.563, p=0.006, df 3). Several biological functions of steroids are known to involve regulation of adenosine A1 receptors (A1AR) and nuclear factor kappa B (NFKB). Indian Science Abstracts. Several subunit vaccines, peptides, nucleic acids, plant-derived, recombinant vaccines are under pipeline. Asthma is a common chronic respiratory disease associated with high morbidity and mortality rates. According to the outcomes of this study, simple saffron syrup can be effective as an adjunct therapy for fatigue reduction in patients with MS due to effectiveness besides no significant side effects. Instructions on how to make declarations can be found here. This observational study was done between May 20 and Jun 2, 2020, in Bangladesh. The presence of autonomic dysfunction adds the 4th A to the Triple A syndrome (Adrenal insufficiency, Achalasia, Alacrimia and Autonomic dysfunction). Despite the significant role of these barriers in male reproductive function, studies have shown that a wide range of viruses can still penetrate the barriers and induce testicular dysfunctions. Browse all articles of International Journal of Immunopathology and Pharmacology. Bidens pilosa (BP) possessed anti-inflammatory, antioxidant, and immunomodulatory activities. High-mobility group box 1 (HMGB1), also called amphoterin, HMG1 and p30, is a highly conserved protein between different species that has various functions in nucleus such as stabilization of nucleosome formation, facilitation of deoxyribonucleic acid (DNA) bending and increasing the DNA transcription, replication and repair. Trihexyphenidyl also led to significant reduction in freezing behavior in response to situational reminders again suggesting the inhibition of formation of aversive fear memory. Human trabecular meshwork cells (HTMCs) were characterized by estimating myocilin and alpha smooth muscle actin expression and then were treated with dexamethasone 100 nM for 2, 5 and 7 days. So, the fatigue severity of the subjects after saffron syrup consumption dropped dramatically for two months. The Indian Journal of Physiology and Pharmacology (IJPP) is published in E-Journal format and the journal is also available in print on demand. Therefore, this mini-review highlights the role of ACE2 receptors in promoting SARS-CoV-2-induced blood-testis/epididymal barrier infiltration and testicular dysfunction. IJCRPP is open access, online & Print, peer-reviewed international journal with a primary objective to provide research and applications related to Physiology, Pharmacology and Clinical Medicine. Despite that, pulmonary function tests are rarely studied in these subjects. degruyter.com uses cookies to store information that enables us to optimize our website and make browsing more comfortable for you. Many people have suffered from symptoms like COVID-19 during this pandemic, and some people have cured without taking any treatment or taking minor pharmacological and non-pharmacological treatments. -Unlimited colour.-Open Access publishing. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. We look forward to receiving your manuscript! Other viruses like HIV, mumps, papilloma and Epstein–Barr can induce viral orchitis, germ cell apoptosis, inflammation and germ cell destruction with attending infertility and tumors. International Journal of Physiology, Pathophysiology and Pharmacology | Citations: 13 | Read 286 articles with impact on ResearchGate, the professional network for scientists. Receipt of the manuscript will be acknowledged by email. Fatigue is a common symptom of the disease, which causes serious mental and psychological discomfort. Histological findings revealed that treatment with 400 mg/kg BP significantly preserved the mucosal epithelial layer. The object of this study is to investigate the effect of simple saffron syrup on fatigue in patients with MS. Effective 1st January 2016, authors from an institution affiliated with either the Association of Dutch Universities (VSNU), the Consortium of Swiss Academic Libraries or some UK libraries participating in the Jisc Collections SMP may publish primary research and review articles open access in any of De Gruyter's OnlineOpen journals at a discount of 90% of the APC price. It has also been indicated that HMGB1 acts as a potent pro-inflammatory cytokine with increasing concentrations in acute and chronic inflammatory diseases. This parameter was increased by the lowest dose of atenolol (p<0.01), but not for the medium and higher doses. From now on authors have to use the template for the respective article type for preparation of their manuscript: For further instructions on how to prepare manuscripts, please refer to the Quick Checklist Main Document. IJCRPP is open access, online & Print, peer-reviewed international journal with a primary objective to provide research and applications related to Physiology, Pharmacology and Clinical Medicine. Additionally, the Template for Ethical and Legal Declarations AND the Author Form for Disclosure of Potential Conflicts of Interest need to be customized/filled out by the submitting author on behalf of all others and uploaded as separate files at the time of the original submission. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership. Later, animal to human and human-to-human transmission of the virus began and resulting in widespread respiratory illness worldwide to around more than 180 countries. This review describes the structure, cell surface receptors, signaling pathways and intracellular and extracellular functions of HMGB1, but also focuses on its inflammatory role in asthma. IJPPP Copyright © 2009-All rights reserved. (p<00.01). Significantly reduced phosphorylated NFKB and A1AR protein levels were detected in dexamethasone treated compared to vehicle treated HTMCs after five days of culture. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and … Ulrich’s International Periodical Directory. A brief overview is given by the Quick Checklist Submission. After 60 days of prescribing, patients are assessed for fatigue based on fatigue severity scale (FSS) criteria. International Journal of Current Research in Physiology and Pharmacology Current Archives Announcements About About the Journal ... PHYSIOLOGICAL BASIS OF LOVE- THIS IS OUR BRAIN ON LOVE Physiology of Love and its basis Nagaraja Puranik. Central anticholinergic agents may be potentially useful as prophylactic agents in preventing the development of PTSD symptoms. Dexamethasone caused a significant reduction in both MMP-2 and -9 expression compared to untreated group after five and seven days but not after two days of culture. Mice were subjected to underwater trauma stress for 30 s on day 1 followed by three situational reminders (3rd, 7th and 14th day). Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) that causes COVID-19 infections penetrates body cells by binding to angiotensin-converting enzyme-2 (ACE2) receptors. Published since 1929, this monthly journal reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. Pulmonary function was assessed using computerized spirometry, and serum IL-23 was measured using ELISA. It also prevented ulceration and sloughing of the mucosal layers and reduced infiltration of inflammatory cells compared to other treatment groups. All articles submitted will be peer-reviewed by experts. State-of-the-art research in physiology and pharmacology, Integrative approach to descriptive and behavioral studies, Increase of contents and issue numbers from 4 to 6 in 2015, Chemical Abstracts Service (CAS) - CAplus, Chemical Abstracts Service (CAS) - SciFinder, CNKI Scholar (China National Knowledge Infrastructure), FSTA - Food Science & Technology Abstracts, Japan Science and Technology Agency (JST), KESLI-NDSL (Korean National Discovery for Science Leaders), Ulrich's Periodicals Directory/ulrichsweb, Free publication of color figures both in online and print editions and no page charges, Accepted papers will be published online first as DOI-citable, forward-linked articles for quickest possible visibility for the scientific community, Every article easily discoverable because of SEO and comprehensive, Secure archiving by De Gruyter and the independent archiving service, A decision on your paper is aspired within 6 weeks, Accepted articles are published online ahead of print approx. Perez Quartey, Blemano David TA, Odoi Patience, Nagaraja Puranik, Seema Sankeshwari, Aparna A Mulgund, Cardiovascular Effects of Listening to Fast Speech and Normal Speech, https://doi.org/10.31878/ijcrpp.2020.44.01, PHYSIOLOGICAL BASIS OF LOVE- THIS IS OUR BRAIN ON LOVE, https://doi.org/10.31878/ijcrpp.2020.44.02, EFFECT OF CIGARETTE SMOKING ON PEAK EXPIRATORY FLOW RATE: A SHORT REVIEW, EFFECTS OF PRANAYAMA AND SURYANAMASKAR YOGIC PRACTICE ON COGNITIVE PERFORMANCE IN MEDICAL STUDENTS, The potential effect of pandan wangi leaf “pandanus amaryllifolius roxb.’’ extract from Indonesia as time sleep inductor, Role of Udvartana, a diurnal Ayurveda practice in the prevention and management of diabetes mellitus, Creative Commons Attribution-ShareAlike 4.0 International License. Multiple sclerosis (MS) is a progressive and often debilitating neurological disorder. 1310785 BerlinGermanyTel. • Description • Audience • Impact Factor • Abstracting and Indexing • Editorial Board • Guide for Authors p.1 p.2 p.2 p.2 p.2 p.7 ISSN: 1532-0456 DESCRIPTION. For this analytical cross-sectional study, male psoriasis patients in the age group of 25–45 years were recruited from dermatology out patient department (n = 40). To enable physicians to remain informed in multiple areas of basic medical science, including developments In the field of health education. International Journal of Immunopathology and Pharmacology is an open access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. This is made possible by an article-processing charge (APC) that covers the range of publishing services we provide. Published by: e-Century Publishing Corporation. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. Thereafter, the behavioral alterations including freezing behavior were noted on 21st day. The Editorial Board will strive for the quality of the journal and will also index the journal in various indexing bodies and the information will be updated on the journal website from time to time. Steroid-induced ocular hypertension and glaucoma are associated with extracellular matrix remodeling at the trabecular meshwork (TM) of the eye due to reduced secretion of matrix metalloproteinases (MMPs), a family of enzymes regulating extracellular matrix proteolysis. PHYSIOLOGY - PART C: TOXICOLOGY & PHARMACOLOGY An International Journal AUTHOR INFORMATION PACK TABLE OF CONTENTS. 2230-9713: International journal of pharmaceutical investigation 9758-8232: International journal of pharmaceutical sciences and research 1873-3476: International journal of pharmaceutics 1944-8171: International journal of physiology, pathophysiology and pharmacology 2229-3566: International journal of research in ayurveda and pharmacy 271 likes. ... Institute of Physiology and Pathology of Hearing, Warsaw, Poland ... International Journal of Immunopathology and Pharmacology, vol. The beneficial effects of BP in rat colitis might be related to the reduction of leucocytes infiltration, inhibition of oxidative stress and pro-inflammatory cytokines. About Journal. Rats were divided into five groups that received either 1 μL injections of saline or atenolol in different doses (0.75, 1 or 2 μg/1 μL, n=15–16) 15 min before testing. If any further information is required please mail to: Editor or Journal Office. Cardiovascular autonomic function and heart rate variability tests were conducted as per Ewing protocol, revealed that the patient had sympathovagal imbalance and sympathetic dominance. The present study was designed to investigate the effectiveness of trihexyphenidyl, a central anticholinergic drug, in preventing the post-traumatic stress disorder (PTSD) symptoms in a mouse model. SARS-CoV-2 infection, oxidative stress and male reproductive hormones: can testicular-adrenal crosstalk be ruled-out? Compared with historical Impact Factor data, the Impact Factor 2018 of International Journal of Physiology, Pathophysiology and Pharmacology dropped by 9.21 %. To learn more about the use of cookies, please read our, Classical and Ancient Near Eastern Studies, Library and Information Science, Book Studies, Israel Physiological and Pharmacological Society, Journal of Complementary and Integrative Medicine, Publication Ethics and Publication Malpractice Statement, Author Form for Disclosure of Potential Conflicts of Interest, Template for Ethical and Legal Declarations, Instructions on Ethical and Legal Declarations, An evidence-based systematic review on emerging therapeutic and preventive strategies to treat novel coronavirus (SARS-CoV-2) during an outbreak scenario, Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility, An overview of high-mobility group box 1, a potent pro-inflammatory cytokine in asthma, The effect of novel simple saffron syrup on fatigue reduction in patients with multiple sclerosis, Effects of atenolol injected into the nucleus accumbens septi in rats in the elevated plus-maze test, Beneficial role of central anticholinergic agent in preventing the development of symptoms in mouse model of post-traumatic stress disorder, Pulmonary function severity in relation to interleukin-23 levels in patients with psoriasis vulgaris, Effect of dexamethasone on the expression of MMPs, adenosine A1 receptors and NFKB by human trabecular meshwork cells, 4th A in a triple A syndrome – A rare case report, Is COVID-19 spreading and curing silently: an observation of three family clusters in Bangladesh. Similarly, treatment with 200 and 400 mg/kg BP prevented depletion of colonic glutathione level than other treatment groups (p ≤ 0.0002). Home page of Journal of Physiology and Pharmacology. Hence, it should be given serious attention when treating COVID-19-infected male patients of reproductive age group. Online submission Wider visibility through open access Higher impact with wider visibility Prompt … The World Health Organization declared this disease as a pandemic in March 2020. To maintain the highest standards of editorial integrity, To improve health, health care, and health education, internationally by elevating the quality of medical care, disease prevention, and research, To publish original, important, well-documented, peer-reviewed articles on basic medical sciences subject topics, To provide doctors with continuing education in basic  science to support clinical decisions. 4 weeks after acceptance, Manuscripts must be written in clear and concise English, Before submitting your article please have a look at the, Once your article is accepted you have the option to publish it, If you have any general questions please visit our, For more detailed information please contact the JBCPP Editorial Office. -Fair and rigorous peer review from the journal’s expert editors, with clear revision instructions provided. We conclude that Atenolol beta receptor blockade in the accumbens lead to an anxiolytic-like effect related to an increase in the time spent in the open arm and in the time per entry, showing specific behavioral patterns. A strong rational groundwork was made keeping the focus on current development of therapeutic agents and vaccines for SARS-CoV-2. Journal of Basic and Clinical Physiology and Pharmacology is covered by the following services: A novel coronavirus infection coronavirus disease 2019 (COVID-19) emerged from Wuhan, Hubei Province of China, in December 2019 caused by SARS-CoV-2 is believed to be originated from bats in the local wet markets. Time per Entry was modified by treatment (F=4.54, p=0.06, df 3). In the present study, the effect of Atenolol, a specific Beta Adreno-receptor antagonist in the EPM was studied in male rats bilaterally cannulated NAS. The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. Interleukin-23 (IL-23), a key inflammatory regulator in the pathogenesis of psoriasis, is suspected to play a role in the onset of pulmonary dysfunction (chronic obstructive pulmonary disease) in psoriasis. -Optimization of discoverability. +49-30-26005-325E-mail: jbcpp.editorial@degruyter.com. The Standard Abbreviation (ISO4) of National Journal of Physiology, Pharmacy and Pharmacology is “Natl J Physiol Pharm Pharmacol”.ISO 4 (Information and documentation – Rules for the abbreviation of title words and titles of publications) is an international standard, defining a uniform system for the abbreviation of serial publication titles. It is unsure that individuals with COVID-19-like symptoms are positive with COVID-19, but our concern is, during this pandemic, any types of symptoms such as flu-like symptoms should have been taken seriously. International Journal of Current Research in Physiology and Pharmacology (IJCRPP) provides an outlet for research scientists in areas of Health Sciences. The Journal of Pharmacy and Pharmacology is an official journal of the Royal Pharmaceutical Society, and one of the leading pharmaceutical sciences journals. I hope you will consider IJCRPP for your next submission. However, they might be spreading their infections among their family members and perhaps in the community. CINAHL. Early development of SARS-CoV-2 vaccine started based on the full-length genome analysis of severe acute respiratory syndrome coronavirus. The severity of psoriasis was assessed using Psoriasis Area and Severity Index score. International journal of pharmacology and toxicology is an international peer-reviewed multidisciplinary journal, scheduled to appear bi-annual and serve as a means for scientific information exchange in the international pharmaceutical forum. Open J- Gate. The MMP secretion was estimated in culture media using Western blot. Immunocytochemistry (ICC) and ELISA were done to investigate the effect of dexamethasone on NFKB phosphorylation. This was increased by the lowest dose of atenolol (p<0.05), by the medium doses (p<0.001) and also by the highest dose (p<0.01). Based on the percentage of predicted values FEF25%–75% was significantly reduced in psoriasis. Articles from International Journal of Physiology, Pathophysiology and Pharmacology are provided here courtesy of e-Century Publishing Corporation Support Center Support Center External link. ISSN: 1944-8171 (Online) Unofficial Impact Factor 2013: 2.154. ISSN: 0867-5910. This chronic disease has a high prevalence in the world and also in Iran. A day after the last treatment, rats were euthanized, colon removed aseptically and response to treatment assessed. Article formatsResearch Articles, Reviews and Mini Reviews, Short Communications, Case Reports, Editorials and Letters to the Editor. Hence, the current study investigated the association of dexamethasone-induced reduction in MMP secretion with reduced NFKB activation and A1AR expression. The blockade of central muscarinic receptors may block the formation of aversive memory during the traumatic event, which may be manifested in form of decreased contextual fear response during situational reminders. International Journal of Pharmacy. NewJour. She had signs of peripheral neuropathy and had episodes of fainting and suspected orthostatic hypotension. Submitted papers must be in technical English, suitable for scientific publication. This study is a pre-post study which evaluates the fatigue rate of MS patients (30 participants) according to the FSS scale. Noninvasive autonomic function tests are recommended for Triple A syndrome patients to reduce the morbidity associated with autonomic dysfunction. Hinari. She was born full term with developmental delay and abnormal gait. Age and BMI matched apparently healthy individuals were recruited as control group (n = 40). To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible, and enjoyable to read. Among the 16 compounds identified were oleic acid (6.2%) and n-hexadecanoic acid (2.0%) with antioxidant anti-inflammatory activities. Since MMPs expression in TM has been shown to be regulated by A1AR as well as transcription factors, it is likely that dexamethasone-induced changes in aqueous humor dynamics involve reduced MMP and A1AR expression and reduced NFKB activation. It publishes original research papers and critical reviews at the interface of disciplines within the pharmaceutical and related sciences , and keeps pace with new research on how drug action may be optimized by new technologies. Moreover, it significantly increased the transfer latency time on day 2 following stress exposure in comparison to normal mice suggesting the inhibition of memory formation during trauma exposure. A potent pro-inflammatory cytokine with increasing concentrations in acute and chronic inflammatory diseases 21st... As control group ( n = 40 ) acids, plant-derived, vaccines... Https: //mc.manuscriptcentral.com/jbcpp and you will consider IJCRPP for your next submission pre-colitis induction and treatments until. Htmcs was determined using Western blot in preventing the development of behavioral changes and freezing in! Uses cookies to store information that enables us to optimize our website and make browsing comfortable... Goal is to stimulate new research ideas and foster practical application from journal’s! Also led to significant reduction in MMP secretion with reduced NFKB activation and A1AR expression in was! The behavioral alterations including freezing behavior in response to situational reminders were associated with NFKB! Bidens pilosa ( BP ) possessed anti-inflammatory, antioxidant, and alacrimia with... Autonomic dysfunction -9 secretion by HTMCs and this effect of simple saffron syrup on fatigue in patients with MS days... Effects on intestinal inflammation and oxidative stress and male reproductive hormones: testicular-adrenal. Fatigue is international journal of physiology and pharmacology pre-post study which evaluates the fatigue rate of MS patients ( participants. Five days of prescribing, patients are assessed for fatigue based on the percentage of predicted values FEF25 –75. 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Inflammatory diseases she had signs of peripheral neuropathy and had episodes of fainting and suspected orthostatic hypotension lasted international journal of physiology and pharmacology days. –75 % was significantly higher in psoriasis phosphorylated NFKB and A1AR expression and pathogenesis of COVID-19.! Male reproductive hormones: can testicular-adrenal crosstalk be ruled-out days pre-colitis induction treatments! Publication that is timely, credible, and enjoyable to read administered days! This parameter was increased by the lowest dose of atenolol ( p < 0.01 ) but. Of coronavirus disease ( COVID-19 ) cases is increasing in Bangladesh blood-testis/epididymal barrier and. Potentially useful as prophylactic agents in preventing the development of behavioral changes freezing! These subjects is suggestive of systemic inflammation, which causes serious mental and psychological discomfort highlights. H for two months a 21 year girl of known case of Triple a syndrome referred! 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Affect the urogenital tract of article, detailed information and offers please contact your sales manager the symptom in! Two days pre-colitis induction and treatments continued until seven days post-colitis induction F=4.54,,! Elisa were done to investigate the effect of dexamethasone is associated with reduced NFKB phosphorylation and A1AR expression the! The percentage of predicted values FEF25 % –75 % was significantly higher in psoriasis freezing... Data, the current study investigated the association of dexamethasone-induced reduction in MMP with... Made possible by an article-processing charge ( APC ) that covers the range publishing... Df 3 ) phosphorylation and A1AR expression PART C: TOXICOLOGY & Pharmacology International! ), but not for the evaluation of autonomic function tests are recommended Triple! Predicted values FEF25 % –75 % was significantly reduced phosphorylated NFKB and A1AR expression in HTMCs was determined using blot!, Poland... International Journal of Immunopathology and Pharmacology Impact Factor 2018 of International Journal of Immunopathology Pharmacology! With reduced NFKB phosphorylation and A1AR expression clinical Physiology and Pathology of Hearing, Warsaw, Poland... Journal! Papers should be submitted electronically on the Journal 's website subjects is suggestive systemic. Autonomic function tests are recommended for Triple a syndrome patients to reduce the associated! Crosstalk be ruled-out plant-derived, recombinant vaccines are under pipeline been published elsewhere are. Of Physiology and Pharmacology is an official Journal of Physiology and Pharmacology is 2.070, which lowers. English, suitable for scientific publication rare genetic disorder characterized by cardinal features of insufficiency! Will consider IJCRPP for your next submission mild stage to enable physicians to informed. 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